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We also know that harms are systematically under reported in RCTs (Hodkinson et al 2013)

An evidence and gap map identified absolute gaps in evidence comparing the effects of nicotine EC to cytisine, bupropion, and nicotine pouches."We set out to determine if scientists agree on whether nicotine e-cigarettes help people quit smoking," senior author Jamie Hartmann-Boyce, Ph.D., from the University of Massachusetts at Amherst, said in a statement

So what are those issues

The Hidden Dangers of Vaping & Nicotine Pouches Many people think that vaping and nicotine pouches are easier to quit than cigarettes

Further reading [edit] Cadmium: From Toxicity to Essentiality