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J Mar Sci Eng 13:71

Apart from its addictive nature, nicotine alters your brain chemistry by quickly boosting dopamine levels, which encourages repeated use

Matsumotot, T

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A comprehensive review published by the American Thoracic Society concluded: Regular smoking of marijuana by itself causes visible and microscopic injury to the large airways that is consistently associated with an increased likelihood of symptoms of chronic bronchitis that subside after cessation of use