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Ethics declarations Ethics approval and consent to participate This article research project approved by Ethics Committee of Mashhad University of Medical Sciences with the code of ethics IR.MUMS.REC.1398.153 (Cod: 980103)

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As significant superoxide source, an uncoupled nitric oxide synthase was identified since a normalization of vascular dysfunction was achieved by administrating the eNOS cofactor tetrahydrobiopterin (BH 4 ) [37] (Fig