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Despite its central role in cancer biology, KRAS has long been considered undruggable due to its high affinity for GTP and the lack of suitable binding pockets for conventional inhibitors 6,7

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Compound 23 (Figure 21) exhibited greater binding affinity with COX-1 and the lowest calculated free energy value with COX-2, compared to other ligands developed by combining NSAIDs with GEP

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