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Pierce, a professor emeritus in the Department of Family Medicine and Public Health at University of California, San Diego, wrote in a commentary of the study
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130 It has been reported that the LIR domain in BCL2L13 selectively binds to GABARAP, GABARAP-L, and LC3C to promote mitophagy, while the Q277C/Q278I mutation in the LIR domain enhances its binding to LC3B, indicating that BCL2L13 can bind different LC3/GABARAP family proteins according to varying conditions during the induction of mitophagy
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