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B4Crry is linked to murine complement receptor 1 (CR1)-related gene/protein y (CRRY), an ortholog of the human complement receptor 1 (CR1), and serves as a targeted complement inhibitor that blocks all complement pathways at the central C3 activation step ( Finally, another study investigated the interaction between smoking and a complement gene polymorphism (C4B*Q0, a silent allele of the C4B gene) in promoting cardiovascular disease morbidity and mortality ( Collectively, the aforementioned studies/findings illustrate the complex role of complement activation and its interplay with environmental factors such as smoking, and highlight the delicate balance between activation and regulation and how that influences the progression of disease