Retatrutide is a weekly injection that is slightly more sophisticated than other GLP-1 drugs because it is a "triple agonist." Unlike current drugs (Zepbound, Ozempic-type medications) that target one or two hormone pathways, retatrutide activates three hormone receptors (GIP, GLP-1, and glucagon) at once
CAT and GPX [one of the main peroxidases (POX)] further detoxify H 2 O 2 into water and oxygen 11
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GS: glutamine synthetase
Once FoB are activated, their demand for GSH increases to cope with accumulating ROS
doi: 10.1177/0300060518786918 171 IwabuchiTYoshimotoCShigetomiHKobayashiH