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Whether that reshuffling translates into anything functional, into real changes in how a cell ages, behaves, or secretes molecules, is a separate question each study has to test on its own terms

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Future Drug Discovery

FOXO4-p53 Disruption Moderate Research Detailed mechanistic studies confirm that FOXO4-DRI achieves its senolytic effects through precise disruption of the protective FOXO4-p53 protein interaction that allows senescent cells to evade apoptosis and persist in tissues