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Even if fertilisation occurs, high DNA fragmentation leads to poor embryo development and higher miscarriage rates Reduced seminal antioxidants: Tobacco depletes zinc, selenium, and Vitamin C in seminal plasma nutrients that protect sperm from oxidative damage Tobacco Use and IVF: What the Data Shows The impact of male tobacco use on IVF outcomes is measurable at every stage of the process: Clinical finding: Studies show that couples where the male partner smokes have significantly lower fertilisation rates, lower blastocyst development rates, and higher rates of failed or poor-quality embryos during IVF compared to non-smoking couples

The Hallmark gene set analysis demonstrated that exposure to DA vapor resulted in enriched pathways amongst down- (Fig

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