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Damm P, Mathiesen ER, Petersen KR, et al

amino includes methylamino, ethylamino, dimethylamino, methylethylamino, and the like

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The binding modes of the clinically most widely used DPP-4 inhibitors have been characterized and based on these findings, three different classes of DPP-4 inhibitors have been proposed: Class 1 comprises of saxagliptin and vildagliptin, interacting with the S1- and S2 subsites of the active center and covalently binding with Ser630 of the DPP-4 molecule

This uses gravity to keep stomach contents away from the esophageal opening and can reduce both nausea and acid reflux

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