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[17] Towards the end of the 18th century and in the 19th century, cigar smoking was common, while cigarettes were comparatively rare

1) corroborates the concept of an evolving phenotype and suggests that once a cEDS diagnosis is made (or in the presence of a positive family history) and management guidelines for prevention of primary manifestations are provided (e.g

Smoking also reduces the amount of oxygen flowing to the skin, causing loss of volume and an overall dulling of skin appearance

However, based on what we know so far, professionals are saying that they are ultimately unsafe

45: 24198 Ereshefsky L, Tran-Johnson T, Davis CM, et al

NO Exceptions