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Efficacy of e-cigarettes in reducing smoking and in harm reduction, their safety over the long term, and the effect of their sale on that of combustible cigarettes are all issues that need to be further investigated.

Fairholt also points out that tobacco, " Engraving: Philip Gale and Karel van Mallery - Pelicans Fishing (1595) if not placed in a metal box, is held in a pouch or bag

The 2019 E-cigarette or Vaping Use-Associated Lung Injury (EVALI) outbreak highlighted the potential harms of vaping, and the consequences of long term use remain unknown

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