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CysC release has been shown to be downregulated in response to CS.71 Thus, CS tips the balance of proteinase/anti-proteinase release from AMs, contributing to cell death alongside inadequate repair, with elastolysis and connective tissue destruction, all of which are involved in the pathology of emphysema

The literature suggests that non-dysplastic conditions can trap dye due to mechanical or inflammatory properties rather than glycogen content, impacting specificity [31]

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