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Similar results for Chinese hamsters exposed by the inhalation route to 28 -36 mg/m 3 for 16 h (males only), or by a single oral dose of 15 mg/kg body weight (males) or 10 mg/kg body weight (females), have been reported (Dean & Thorpe, 1972a)

25 In practice, pathogens often employ these mechanisms in combination

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Taking together all the studies discussed in this review, it seems reasonable to conclude that NRF2 is part of the sleep biochemical regulatory network