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depression, anxiety, panic, fears, affective disorder, low self-confidence, negative thinking, and hopelessness) are common features among EDS patients [92, 100,101,102,103,104,105]

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The long-lasting and frequent presence of paan and gutkha in the mouth around the gums leads to inflammation of the oral mucosa, which causes the activation of T-cells and macrophages, and ultimately the release of prostaglandins (PGs)

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