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However, while a positive relationship has been observed between smoking and drinking, the temporality of this relationship remains unclear (Istvan and Matarazzo 1984

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To date, our cigarette filter paper has mainly been used for specialty cigarettes and marketed accordingly

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This is consistent with reports that GSK3 promotes NRF2 degradation, whereas AKT-mediated phosphorylation of GSK3 inhibits this process, thereby stabilizing NRF2 and enhancing its nuclear localization 11,20,26,28