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Unfortunately, due to the small size of the cohorts and disparities of the protocols used, these studies have not given conclusive results of nicotines efficacy in decreasing motor or non-motor symptoms, best daily dosage or method of administration (Thiriez et al., 2011)

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The capacity of the water filter was approximately 200 ml, but for research purposes, 100 ml of distilled water (with a conductivity of 0.05 S) was used