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Characteristics include a white color change that cannot be wiped off with gauze, granularity of the surface, wrinkling, corrugation and/or a thickening of the mucous membrane

Furthermore, because nicotine is readily absorbed through the skin, transdermal patches containing nicotine can be employed

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The PRISMA flow diagram of an updated systematic review on the relationship between smoking and chronic obstructive pulmonary disease conducted on PubMed to update historical review from previous cycles of the Global Burden of Disease Study