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Neuropeptide-expressing fibers, including those positive for SP and CGRP, interact with immune cells such as MCs to initiate neurogenic inflammation and promote the release of type 2 cytokines like IL-4 and IL-13, thereby exacerbating both cutaneous inflammation and pruritus (40, 110)

Zhang W, Lee AM, Jena S, Huang Y, Ho Y, Tietz KT, et al

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