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Also manufactured at Nicaraguan America Cigars, S.A., it is slated for October 2026 delivery with an MSRP of $50 per cigar or $600 per cabinet

Smoking status was measured through self-report, and where possible triangulated with saliva samples and carbon monoxide readings

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Including fibroblasts or other mesenchymal cell populations in co-culture models could be crucial for studying smoke-induced effects, as these cells contribute to extracellular matrix remodeling, fibrosis, and epithelial-mesenchymal interactions, which are key processes in COPD and emphysema progression

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The tax hike, introduced and eventually included in the 2025-27 state budget, was initially opposed by many Republican lawmakers