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When tobacco is used in connection with alcohol, caffeine or illegal drugs, the high is amplified, leading to increased damage of the reward pathway where the dopamine neurons are situated

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Table 4 Longitudinal association between tobacco use and incident restless sleep, Agincourt, South Africa, 20142019 (N=2644) Associations between tobacco use and incident breathing stops In fully adjusted models, daily tobacco smoking (AOR=2.08

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