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Clinical studies Acute cardiovascular effects Acute effects of conventional smoking, such as increased blood pressure, heart rate, and vascular resistance, have been known for decades [155160]

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They claimed that their products caused no adverse side-effects, with the apparent backing of "medical specialists." This advert claimed to prevent "throat irritation and coughing." It was considered uncouth for a woman to smoke at the turn of the 20th century, but as the Prohibition era came to an end, tobacco companies aggressively targeted the untapped female market