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Since SIRT6 has context-dependent (dose-, tissue-, model-dependent) roles in the brain, these findings should be viewed as a plausible, theoretical mechanistic pathway

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These brain regions where nicotine acts are the thalamus, occipital cortex, caudate, and parietal cortex

As early as the late 1960s he had been telling intimates, like his doctor Sir Joseph Stone (later Lord Stone of Hendon), that he did not intend to serve more than eight or nine years as prime minister