Laws that benefit nearly everyone (such as taxing the rich and redistributing their wealth) require violence (with those who persistently disobey tax collectors having their assets seized, for example)
GBD 2015 Tobacco Collaborators
To their great surprise, the nicotine ignored proteins in the between-cell gaps and instead bound directly to a specific receptor on the receiving nerve cell surface
And let's not forget the constant coughing and wheezing, the fatigue, and the inability to do the things you love
Indigenous peoples in the Americas began cultivating tobacco as early as 1400 BC, establishing a long history of growing, trading, and consuming it for its nicotine content
Nicotine smoking concentrations modulate GABAergic synaptic transmission in murine medial prefrontal cortex by activation of alpha7* and beta2* nicotinic receptors