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The heterogeneity in these results is likely multifactorial, arising from variations in study design, population characteristics, and adjustments for key confounders such as BMI and socioeconomic status (SES) 9,10
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In the other 11 studies that did not allow for multiple confounders, the pooled relative risks were 1.20 and 1.68 for one and 20 cigarettes per day, and one cigarette per day had 38% of the excess relative risk for 20 cigarettes per day
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