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Everett Koop Institute at Dartmouth, Hanover, New Hampshire, United States Behavioral Health and Health Policy Practice, Westat, Rockville, Maryland, United States Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, Minnesota, United States Department of Health Behavior, Roswell Park Comprehensive Cancer Center, Buffalo, New York, United States School of Global Public Health, New York University, New York, New York, United States University of California at San Diego, La Jolla, California, United States National Institute on Drug Abuse, National Institutes of Health, Bethesda, Maryland, United States Center for Tobacco Products, Food and Drug Administration, Silver Spring, Maryland, United States Department of Psychiatry and Behavioral Sciences, Medical University of South Carolina, Charleston, South Carolina, United States Axle Informatics, Rockville, Maryland, United States Abstract Introduction: We examined the association between tobacco product use and health-related quality of life (HRQoL) among individuals with chronic obstructive pulmonary disease (COPD) in Waves 15 of the Population Assessment of Tobacco and Health (PATH) Study