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Some sources believe early wild species may have arisen around 6,000 BCE, especially in South America, and there may be several sites of origin for each species throughout North and South America

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Nicotine, a naturally occurring substance found in tobacco plants, can have a range of effects on the user including calmness and mood elevation

A Randomized, single-blind study of Lansoprazole for the Prevention of exacerbations of Chronic Obstructive Pulmonary Disease in older patients

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