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In other words, they make smoking less desirable

Nicotine dependence pharmacogenetics: role of genetic variation in nicotine-metabolizing enzymes

For specialized tobacco and/or vape stores, the longitudinal increase was no longer statistically significant after adjusting for covariates, although it exhibited a trend towards significance (p=0.09)

95% CI: 1.694.61), but among current daily smokers higher pack-equivalent years were not associated with more respiratory symptoms (RR=0.83

it is valid to conduct an extensive epidemiological investigation of the relationship between adult smoking and vertigo and the potential role of covariates (sociodemographic and chronic diseases) as determinants of the risk of vertigo in the Kingdom of Saudi Arabia