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discovered that the combination of metformin and insulin led to a significant increase in the expression of growth factor-associated proteins, impacting the proliferation of endometrial stromal cells ( lncRNA-MEG3/miR-223/GLUT4 and lncRNA-SNHG20/miR-4486/GLUT4 signaling pathways

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Reproduced from Kaneto et al (2021), an open source publication ( Indications: a FIRST LINE drug in the treatment of type II diabetes ( except when contraindicated - see below) Metformin has been in use for over 50 yrs, and remains the most commonly prescribed oral hypoglycemic (DeFronzo & Goodman, 1995