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In terms of individual risk, smoking increases the risk of coronary heart disease by about 2-4 times, lung cancer by 23 times, and COPD by 12-13 times

Tests for heterogeneity suggest evidence for significant horizontal pleiotropy (supplementary Table 2), but MR-Egger intercepts suggest that bias of the estimates by pleiotropy is not likely (supplementary Table 3)

The cultivation of tobacco in the Chesapeake area was essential to solving this problem

The idea that success equals happiness pisses me off

Philip Morris International subsidiaries in Switzerland and Uruguay brought the complaint

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