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Allem, J

Possible long-term effects of nicotine Constant urge to have more nicotine Early aging and skin wrinkles Ongoing stomach issues like ulcers Heart attacks and other heart issues Problems with eyesight Changes to how things taste and smell Loss of muscle Problems with focus, memory, and learning Long-term mental health issues like depression and anxiety

This leads to whats called a G-to-T transversion

Repeated exposure to these drugs of abuse, like nicotine, can alter the brains sensitivity to dopamine, which means one needs to consume more of the substance to feel the same effects

Nicotine and other chemicals in tobacco constrict blood vessels, raise blood pressure, and promote the formation of blood clots, all of which contribute to cardiovascular complications