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These effects are often dose-dependent and may be particularly pronounced during dose escalation

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Spokesman Dr Ram Moorthy says: "The BMA believes that further research is needed into the long-term effects of e-cigarettes, and robust evidence is required to prove how effective they are as smoking cessation aids

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Several other patents for nicotine devices were filed throughout the 1990s, but it would again be over 20 years before the modern e-cigarette was born

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