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Biomarkers of health effects PMI researchers reported a controlled clinical study that applied systems pharmacology and showed that exposure-response gene signature in blood was similarly reduced in smoking cessation or switching to IQOS groups compared to continued smoking 98

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doi: 10.1007/s10865-009-9218-3

The prefrontal cortex, which governs judgment and impulse control, is generally understood to mature closer to age 25