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Thus, chronic exposure to cigarette smoke causes persistent inflammation and oxidative stress in the lungs, leading to repeated repair and remodeling (leading to airway remodeling), stimulating mucus hypersecretion (leading to chronic bronchitis), and degrading the alveolar walls (leading to emphysema) (Fig
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Before 2014 the SPT data were slightly above the prediction trend and slightly below the trend in the last three years
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American Lung Association, SLATI State Reports, 2017