However, the relevance of these findings to humans remains uncertain, as human thyroid C-cells have much lower expression of GLP-1 receptors compared to rodents
High caution: gallbladder disease Rapid weight loss increases gallstone risk, and both semaglutide and keto can individually accelerate this
As of July 2026, Embody advertises compounded semaglutide injections starting at $79 per month and compounded tirzepatide starting at $129 per month under its Summer Start promotion
When to Be More Careful There are situations where estrogen changes may need closer attention: You already have low estrogen You experience rapid or significant weight loss You have a history of hormone-sensitive conditions In these cases, even beneficial weight loss can shift hormones in ways that affect how you feel
Combined with semaglutide's appetite-suppressing effect, some patients experience more nausea during the luteal phase
Both diarrhea and constipation are common, with diarrhea generally reported more frequently (830% of patients) compared to constipation (324%)