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In knockdown experiment, HUV-EC-C, a cell line of HUVECs, was used

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As clinical trials progress, the findings from our work suggest that Teneligliptin may provide a novel, safer alternative to traditional pain management strategies, particularly those reliant on opioids or NSAIDs, which are associated with adverse side effects [12]

It significantly ameliorates high-fat diet-induced structural dysbiosis of the gut microbiota by reducing the abundance of harmful bacteria positively correlated with hepatic lipid deposition (e.g., Lachnospiraceae and Collinsella) and increasing the abundance of beneficial bacteria (e.g., Ruminococcus and Turicibacter), thereby reducing hepatic lipogenesis and ultimately alleviates liver steatosis and lipid accumulation (Wang S