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Review criteria Original studies and review articles that provided information on the determinants and epidemiology of cardiovascular health, as described by the framework presented in this Review, were included from a MEDLINE search supplemented by personal libraries (Supplementary Box 2)

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[7] In 1952, to study the biological likelihood of cancer being linked to smoking, Wynder published an animal study in the US journal Cancer Research that found that tobacco tar was carcinogenic when applied to the skin of mice

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