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Four types of tobacco vendors were purposively selected based on consumer purchasing and product distribution ranking among vendor types in the country

"Our analyses show that there is significant toxicity in harm reduction products, and reduction of carcinogens in harm reduction mainstream smoke does not necessarily reduce the toxicity of unfiltered sidestream smoke." Researchers developed tests with human embryonic stem cells, which are similar to young embryos, to compare the toxicity of mainstream (inhaled) smoke and sidestream smoke from both conventional and harm reduction cigarette brands

These symptoms are nearly identical to those seen in cigarette users, even though pouches dont involve smoke or combustion