what are the bad side effects of smoking cigarettes Short and Long Term on Your Body What happens to your lungs

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The study protocol was according to the research code of the UMCG ( and the national and ethical professional guidelines on the use of human material ( Cohort design and subjects Peripheral lung tissue (containing parenchyma and small airways) was obtained from COPD patients with GOLD stage (III)IV after lung transplantation or from non-COPD control donors and COPD patients with GOLD stage II after tumor resection surgery, taken as far as possible from the tumor and checked for abnormalities by an experienced pathologist

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Additionally, tobacco exposure downregulates p53, a critical tumor suppressor gene, facilitating genomic instability and malignant transformation [34]