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Nicotine has the ability to bind with specific receptors in the brain, blocking them from being able to signal the release of different chemicals acetylcholine, GABA, etc

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The high levels of disease-related biomarkers in smokers were not surprising, Rezk-Hanna noted, since research has shown that cigarette smoking and other forms of combusted tobacco expose users to high levels of chemicals that cause inflammation and oxidative stress

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doi:10.1016/0002-8703(88)90647-3 22