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The World Health Organization (WHO) has stated that the marketing of HTPs should not be permitted until there is conclusive evidence of reduced health risks of HTPs compared with CCs 14

In one study, three groups, comprising of OSCC tumour patients, high-risk individuals (smokers and alcohol users without signs of OSCC) and healthy individuals, were analysed for microbial species and abundance (either at tumour sites of OSCC subjects or normal mucosa in high-risk and healthy subjects) [100]