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Lancet Infect Dis

The offense, however, was an issue

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Furthermore, increases in oxidative stress markers and proinflammatory cytokines occurred in cigarette smoke- but not e-cigarette-exposed animals (144)

did not run a dedicated analysis containing solely never-smoking adults, but rather statistically adjusted for smoking status (i.e., had smoking status as a control variable, using never-smoking as the reference group)