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Tobacco Smoking and E-Cig Vaping in Worsening of Other Neurological Diseases and Nicotine-CNS Drug Interactions Alzheimers Disease Alzheimers disease (AD) is the most common cause of elderly-age dementia and is characterized by the accumulation of amyloid- (A) protein in extracellular senile plaques and neurofibrillary tangles due to intraneuronal tau deposition (Mucke 2009)

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