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These mouse studies appear relevant to human disease, as a large number of studies have shown that polymorphisms in PON1 are associated with increased risk for atherosclerosis (265)

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It also induces Heme oxygenase-1 (HO-1) , an enzyme with powerful anti-inflammatory properties, and $\gamma$-Glutamylcysteine synthetase (GCS) , the rate-limiting enzyme required for the body to synthesize its own glutathione , the master antioxidant

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