Longitudinal studies integrating metagenomic, transcriptomic, metabolomic, methods with clinical results may help us ascertain the relationships between smoking, microbiome, and pathological mechanism in diseases
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Therefore, together, with the large changes in protein expression (Fig
At this time, microorganisms with cellulolytic and hemicellulolytic abilities (e.g., Aspergillus , Bacillus ) become the dominant groups, which continue to degrade macromolecular substances and provide nutrients for other microorganisms ( Nitrogen sources in cigar tobacco leaves include protein, amino acid, nicotine and other nitrogen-containing compounds, among which nicotine is a unique nitrogen source and carbon source in cigar tobacco leaves, and is the core nutritional factor driving the assembly of nicotine-degrading microbial communities (Meng et al., 2010
