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There is also the case of various illegitimate forms of tobacco that are available on the market

The WHO emphasizes that tobacco is not only killing people through smoking but also harming the planet that sustains life itself (WHO News)

Cigarette smoke contains reactive oxygen species (ROS) which can be directly cytotoxic to epithelial cells and trigger an acute inflammatory response, which is further exacerbated by bacterial and viral infections

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Instead of being packed with tobacco, e-cigarettes use cartridges that are filled with liquid that can deliver a much higher dosage of nicotine