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The human dopamine transporter (hDAT) contains a high-affinity, extracellular, and allosteric Zn 2+ (zinc ion) binding site which, upon zinc binding, inhibits dopamine reuptake, inhibits amphetamine-induced hDAT internalization, and amplifies amphetamine-induced dopamine efflux

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Since peaking in 1996-1997, smoking rates have fallen by 71 percent among 12th graders (from 36.5 percent to 10.5 percent who smoke), by 84 percent among 10th graders (from 30.4 percent to 4.9 percent) and by 88 percent among 8th graders (from 21 percent to 2.6 percent)

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