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However, that signal also fell short under the more rigorous analysis

Jeong YG, Park JH, Khang D

Additionally, mechanical stretching of cardiac fibroblasts (as opposed to cardiomyocytes) leads to the release of IL-1, which triggers leukopoiesis in the bone marrow and at extramedullary sites

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It has been associated with anti-CTLA-4 and anti-PD-1/PD-L1 agents, including ipilimumab, durvalumab, avelumab, pembrolizumab, nivolumab, and atezolizumab