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Considering both exposure pathways, the overall carcinogenic risk is primarily driven by inhalation, with Ni and Cd being the metals of greatest concern

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The proportion of free nicotine for easy absorption is higher when smoke is alkaline, and nicotine absorption depends on salivary pH 23,24

Further, we showed that weight gain leads to potentially dangerous health outcomes (Figure 2)

Brookman-May SD, Campi R, Henriquez JD, Klatte T, Langenhuijsen JF, Brausi M, et al