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Later defined as a great circle equidistant from the North and South poles

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Cuba's more mature cigarette smokers will soon discover that economics is no respecter of borders, trade embargoes or even vices

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Given the wide variability in smoking behaviors, the controlled use period of the study was intended to provide some degree of standardization of the nicotine dose associated with each of the study products to better understand potential influences of different vehicles, flavor characteristics and nicotine content on measured parameters